| 姓名： | 哈伟 | 性别： | 男 |
|---|---|---|---|
| 学科类别： | 分析化学、有机化学 | 职务： | 天然药物与化学测量研究中心副主任 |
| 学历： | 博士 | 职称： | 研究员 |
| 电话： | 0931-4968121 | 传真： | 0931-4968019 |
| 电子邮件： | hawei2012@licp.cas.cn | ||
| 通讯地址： | 甘肃省兰州市天水中路18号 | ||
简 历：
教育经历：
2006年9月-2011年6月：兰州大学功能有机分子化学国家重点实验室/中国科学院成都生物研究所，博士（有机化学，超分子化学）
2002年9月-2006年6月：兰州大学，学士（化学）
工作经历：
2020年8月-至今，研究员，中国科学院兰州化学物理研究所
2015年8月−2020年8月：副研究员，中国科学院兰州化学物理研究所
2012年6月-2015年8月：助理研究员，中国科学院兰州化学物理研究所
2011年7月-2012年5月：助理研究员，中国科学院成都生物研究所
研究方向：
获奖及荣誉：
1.获奖项目名称：重要中草药化学成分与靶酶筛药和智能释药技术体系研究，甘肃省自然科学奖，二等奖，排名第二，2021年度；
2.获奖项目名称：食品药品的固相萃取新材料与分析新技术，甘肃省自然科学奖，二等奖，排名第二，2023年度；
3.入选2017年度中国科学院“青年创新促进会”会员；
4. 入选2023年度“甘肃省陇原青年英才”；
5. 入选2024年度“甘肃省领军人才”（第二层次）。
承担科研项目：
1.甘肃省科技厅，甘肃省研产融合科技攻关赋能计划项目，2025.05-2027.05，在研，参与，290万元
2.甘肃省科技厅，科技重大专项项目，2025-2027，150万元，在研，主持
3.中华人民共和国科学技术部，国家重点研发计划项目，2021-07 至 2024-06，65万元，结题，主持
4.中华人民共和国科学技术部,国家重点研发计划，2017-07至2020-12，949万元，结题，参与
5.国家自然科学基金委，面上项目，2023-01-01至2026-12-31，54万元，在研，主持
6.国家自然科学基金委员会，联合基金项目，2022-01-01至2025-12-31，256万元，在研，参与
7.国家自然科学基金委，青年基金项目，2015-01至2017-12，25万元，已结题，主持
8.中国科学院，“西部之光”青年学者A类项目，2016-01至2019-09，50万元，结题，主持
代表论著：
1.Xiao-Kang Fu, Rui Ma, Li-Juan Kang, Pian Jin, Xiao-Bo Zhao, Yan-Ping Shi*, and Wei Ha*, Discovery and Identification of Scarce Terminal Alkyne-Containing Natural Products by Chemical Isotope Labeling-Assisted MALDI-TOF Mass Spectrometry, Journal of Agricultural and Food Chemistry, 2025, 73, 21162-21174.
2. Jing-Yan Kang, Xiao-Bo Zhao, Jia-Qi Huang, Wei Ha, Yan-Ping Shi, Construction of hydrophobic cavity surface of calix[4]arene for efficient extraction of endocrine disrupting chemicals in food, Chemical Engineering Journal, 2025, 518, 164858.
3.Yan-Peng Liang, Qian Gao, Hong Chen, Rui Ma, Xiao-Bo Zhao, Xiao-Jie Jin, Jian Zhang, Yan-Ping Shi, Wei Ha*, Multi-target directed ligands design of 1-O-Acetylbritannilactone derivatives: Dual anti-neuroinflammatory and acetylcholinesterase inhibitory activities, Phytochemistry Letters, 2025, 68, 103011.
4.Xiao-Kang Fu, Si-Qi Han, Xiao-Bo Zhao, Jing-Yan Kang, Wei Ha*, Yan-Ping Shi, Click chemistry-mediated stable isotope labeling combined with HPLC-MS/ MS analysis for highly sensitive determination of steroid hormones, Microchemical Journal, 2024, 206, 111525.
5.Si-Qi Han, Xiao-Kang Fu, Wei Ha*, Yan-Ping Shi, Comprehensive spatial distribution profiling of bioactive emodin in mouse organs using mass spectrometry imaging, Analytical Sciences, 2024, 40,2063-2073.
6.Wei Ha, Rui Ma, Jing-Yan Kang, Yves Iradukunda and Yan-Ping Shi, Green and shape-tunable synthesis of ellagic acid crystalline particles by tannic acid for neuroprotection against oxidative stress, Biomaterials Science, 2024, 12, 3610-3621.
7.Rui Ma, Xu‑Yao Feng, Jiang‑Jiang Tang, Wei Ha* and Yan‑Ping Shi, 5α‑Epoxyalantolactone from Inula macrophylla attenuates cognitive deficits in scopolamine‑induced Alzheimer’s disease mice model, Natural Products and Bioprospecting, 2024, 14, 39.
8.Rui, Ma, Bakhrom Komilov, Cheng-Bo Wang, Komila Alibekovna Eshbakova, Jun-Li Yang, Wei Ha*, Yan-Ping Shi, Sesquiterpenes from Inula macrophylla and their anti-neuroinflammatory activity, Phytochemistry Letters, 2024, 60, 257-263.
9.Xiao-Kang Fu, Si-Qi Han, Wei Ha*, Yan-Ping Shi, Click Chemoselective Probe with a Photoswitchable Handle for Highly Sensitive Determination of Steroid Hormones in Food Samples, J. Agric. Food Chem. 2023, 71, 14814−14824.
10.Wei Ha, Jun-Li Yang, Yan-Ping Shi, Tannic Acid-Modified Silver Nanoparticles for Antibacterial and Anticancer Applications, ACS Appl. Nano Mater. 2023, 6, 9617−9627.
11.Xiao-Kang Fu, Hao-Bo Cao, Yu-Long An, Hui-Di Zhou, Yan-Ping Shi, Guo-Liang Hou, and Wei Ha*，Bioinspired Hydroxyapatite Coating Infiltrated with a Graphene Oxide Hybrid Supramolecular Hydrogel Orchestrates Antibacterialand Self-Lubricating Performance, ACS Appl. Mater. Interfaces 2022, 14, 31702−31714.
12.Wei Ha, Jun-Li Yang, Yan-Ping Shi, Antibacterial metal-phenolic nanosheets as smart carriers for the controlled release of epirubicin hydrochloride, Nanoscale, 2022, 14, 9806–9817.
13.Wei Ha, Guo-Liang Hou, Wu-Jun Qin, Xiao-Kang Fu, Xiao-Qin Zhao, Xiao-Dong Wei, Yu-Long An and Yan-Ping Shi，Supramolecular hydrogel-infiltrated ceramics composite coating with combined antibacterial and self-lubricating performance, J. Mater. Chem. B, 2021, 9, 9852–9862.
14.Wei Ha, Xiao-Bo Zhao, Wei-Hua Zhao, Jiang-Jiang Tangb and Yan-Ping Shi，A colon-targeted podophyllotoxin nanoprodrug: synthesis, characterization, and supramolecularhydrogel formation for the drug combination，J. Mater. Chem. B, 2021, 9, 3200–3209.
15.Xin-Yue Chen, Wei Ha,* Xiao-Jie Jin and Yan-Ping Shi*, PEGylated NALC-functionalized gold nanoparticles for colorimetric discrimination of chiral tyrosine, Analyst, 2020, 145, 7397–7405.
16.Wei Ha, Ze-Hao Wang, Xiao-Bo Zhao, and Yan-Ping Shi, Reinforced Supramolecular Hydrogels from Attapulgite and Cyclodextrin Pseudopolyrotaxane for Sustained Intra-Articular Drug Delivery, Macromolecular. Bioscience. 2021, 21，2000299.
17.Xiao-bo Zhao#, Wei Ha#, Kun Gao, Yan-ping Shi, Precisely traceable drug delivery of azoreductase-responsive prodrug for colon Targeting via multimodal imaging, Analytical Chemistry, 2020, 92, 9039-9047.
18.Xin-yue Chen, Wei Ha*, Yan-ping Shi*, Sensitive colorimetric detection of melamine in processed raw milk using asymmetrically PEGylated gold nanoparticles, Talanta, 2019, 194, 475-484.
19.Xin-yue Chen, Run-tian Ma, Wei Ha*, Yan-ping Shi*, Direct colorimetric detection of aspartic acid in rat brain based on oriented aggregation of Janus gold nanoparticle, Sensors & Actuators: B. Chemical, 2018, 274, 668–675.
20.Wei Ha#, Xiao-bo Zhao#, Xin-yue Chen, Kan Jiang, and Yan-ping Shi, Prodrug-Based Cascade Self-Assembly Strategy for Precisely Controlled Combination Drug Therapy, ACS Appl. Mater. Interfaces 2018, 10, 21149−21159.
21.Xiao-Bo Zhao#, Wei Ha#, Kan Jiang, Juan Chen, Jun-Li Yang, Yan-Ping Shi*, Efficient synthesis of camptothecin propargylamine derivatives in water catalyzed by macroporous adsorption resin-supported gold nanoparticles, Green Chemistry, 2017, 19, 1399-1406.
22.Wei Ha, Xiaobo Zhao, Kan Jiang, Yang Kang, Juan Chen, Bang-Jing Li*, Yan-Ping Shi*, A three-dimensional graphene oxide supramolecular hydrogel for infrared light-responsive cascade release of two anticancer drugs, Chemical Communications, 2016, 52, 14384-14387.
23.Wei Ha, Jing Yu, Juan Chen, Yan-Ping Shi*, 3D graphene oxide supramolecular hybrid hydrogel with well-ordered interior microstructure prepared by a host-guest inclusion-induced self-assembly strategy, RSC Advances, 2016, 6, 94723-94730.
24.Wei Ha, Xin-yue Song, Juan Chen, Yan-ping Shi, A physical entrapment method for the preparation of carbon nanotube reinforced macroporous adsorption resin with enhanced selective extraction performance, Nanoscale, 2015, 7, 18619-18627.
25.Wei Ha, Jing Yu, Xin-Yue Song, Juan Chen, Yan-Ping Shi*, Tunable temperature-responsive supramolecular hydrogels formed by prodrugs as a codelivery system, ACS Applied Materials & Interfaces, 2014, 6, 10623-10630.
26.Wei Ha, Jing Yu, Rui Wang, Juan Chen, Yan-Ping Shi*, Green colorimetric assay for the selective detection of trivalent chromium based on Xanthoceras sorbifolia tannin attached to gold nanoparticles, Analytical Methods, 2014, 6, 5720-5726.
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